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- Annie J. Easley
- Wim Ebbinkhuijsen – COBOL
- John Presper Eckert – ENIAC
- Brendan Eich – JavaScript, Mozilla
- Philip-Emeagwali – supercomputing
- E. Allen Emerson – model checking
- Douglas Engelbart – tiled windows, hypertext, computer mouse
- Andrey Ershov
- Don Estridge (1937–1985) – led development of original IBM Personal Computer (PC); known as "father of the IBM PC"
- Christopher Riche Evans
- David C. Evans – computer graphics
- Shimon Even
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