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- Sir Herbert Baker, influential in South African architecture (1862–1946)
- Denise Darvall, donor for the first human heart transplant (1943–1967)
- Emily Hobhouse, welfare campaigner for South Africans (1860–1926)
- Nkosi Johnson, child who died of AIDS (1989–2001)
- Sandra Laing, victim of racial classification (born 1955)
- Breaker Morant, Boer War soldier (1864–1902)
- Napoléon Eugène, last of Napoleons who died in Zulu war (1856–1879)
- Hector Pieterson, poster victim of the Soweto riots (1964–1976)
- Mrs. Ples, homonid fossil (born c. 2.6 to 2.8 million years ago)
- Willem Ratte, soldier and criminal (born 1948)
- Rosenkowitz sextuplets, first known set of sextuplets to survive their infancy (born 1974)
- Adam Tas, colonial activist (1668–1722)
- Taung Child, homonid fossil (born c. 2.5 million years ago)
- Louis Washkansky, recipient of first human heart transplant (1913–1967)
- Wolraad Woltemade, colonial hero figure (c. 1708–1773)
- Paul Lloyd Jr, first ever South African WWE Superstar, son of successful SA wrestling promoter Paul Lloyd (born 1981)
Read more about this topic: List Of South Africans
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