Louie may refer to:
- Louie (TV series), by comedian Louis C.K.
- Louie (animated series), a cartoon about a young rabbit who draws pictures and they come to life.
- "Louie" (song), by Blood Raw
- "Brother Louie" (Hot Chocolate song), by Hot Chocolate
- "Brother Louie" (Modern Talking song), by Modern Talking
- Louie the Bear, the St. Louis Blues mascot
- Louie the Laker, the Grand Valley State University mascot
- Louie the Lumberjack, the Northern Arizona University mascot
- King Louie, a Jungle Book character
- Louie Bellson (1924–2009), Italian-American jazz drummer
- Louie Spence (born 1969), British dancer
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