Lowndes ( /ˈlaʊndz/) is a surname, and may refer to:
- Christopher Lowndes (1713–1785), early settler and merchant at Bladensburg, Maryland
- Craig Lowndes, racing driver
- Jessica Lowndes
- Lloyd Lowndes, Jr. (1845–1905), U.S. politician and Governor of Maryland
- Marie Adelaide Belloc Lowndes
- Rawlins Lowndes
- Robert A. W. Lowndes (1916–1998), science fiction writer and editor
- Thomas Lowndes (astronomer)
- Thomas Lowndes (congressman)
- William Lowndes, various including
- William Lowndes (British politician) (1652–1724) British politician and Secretary to the Treasury
- William Lowndes (congressman) (1782–1822) U.S. Congressman from South Carolina
- William Selby Lowndes
- William Thomas Lowndes, English bibliographer, whose principal work, The Bibliographer’s Manual of English Literature took 14 years to compile
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