Lys may refer to any of the following:
- Places
- The Lys or Leie, a river in France and Belgium
- Lys (Dora Baltea), a stream of Aosta Valley in Italy
- Lys, Pyrénées-Atlantiques, a commune in the Pyrénées-Atlantiques department in France
- Lys (département), a département during the First French Empire, now in Belgium
- Les Lys, a Premier cru vineyard in Chablis
- Lys, an old orthography of Liss, Hampshire, England
- LYS can also refer to a Local Yarn Shop for knitters or crocheters
- Aviation
- LYS, the IATA Airport Code for Lyon-Saint Exupéry Airport
- Sailing
- LYS, a sailing handicapping system
- Battles
- Battle of the Lys, a World War I battle in the spring of 1918
- Fiction
- Lys is the name of a city in Arthur C. Clarke's book The City and the Stars.
- Lys is also the name of a city in George R. R. Martin's epic series A Song of Ice and Fire.
- Heraldry
- Fleur-de-lys or Fleur-de-lis, a stylized representation of a lily or iris, used in heraldry
- Science
- Lys is an abbreviation for the amino acid lysine
- People
- Francis John Lys (1863–1947), British lecturer and academic administrator
- Jan Lys (c1590-1629), a German painter
- Lya Lys (1908–1986), German-born actress
- Lys Assia (born 1926, Rupperswil), Swiss singer
- Lys Mouithys (born 1985), Congolese football player
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