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- Mac, Gaelic for "son", a prefix to family names often appearing in Irish and Scottish names
- MAC, Amtrak station code of Macomb (Amtrak station), Illinois, United States
- Mac (Beanie Baby), a Beanie Baby cardinal produced by Ty, Inc. in 1999
- Mac (novel), by John MacLean
- Mac (or Big Mac), nickname for the Oklahoma State Penitentiary located in McAlester, Oklahoma
- Mac, informal name of McMaster University in Canada
- Mac-10 (Military Armament Corporation Model 10, officially the M10), a highly compact, blowback operated machine pistol
- Mac-11 (Military Armament Corporation Model 11), a sub-compact version of the Model 10 machine pistol
- Fleetwood Mac, an influential rock group
- Macaroni, a type of pasta
- The Macdonald Campus of McGill University, Canada
- Mackintosh, a raincoat made of rubberized cloth (e.g. Jet-Black Mac)
- Magnetic Accelerator Cannons, fictional coilguns used by factions of Halo in the Halo video game series
- Manhattan Association of Cabarets & Clubs
- Michigan Agricultural College, the former name of Michigan State University
- Modern adult contemporary, a radio format
- Modern Army Combatives, hand-to-hand combat training
- Monitored anesthesia care, a form of anesthesia with partial awareness
- Monster Attack Crew, a fictional pilot squadron in Ultraman Leo
- Mount Aloysius College, a Catholic college in central Pennsylvania
- Musical Arts Conference, a marching band competition circuit
- UCLA Marina Aquatic Center, located in Marina del Rey, California
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