The term "Machina" may refer to:
- Machina (band), an alternative metal band
- Machina/The Machines of God, an album by The Smashing Pumpkins
- Machina II/The Friends & Enemies of Modern Music, another album by The Smashing Pumpkins
- A machine-based weapon in Baten Kaitos Origins
- A powered machine in Final Fantasy X
- A 1940's car in Cuba, also known as yank tank
- Deus ex machina, a literary device sometimes used in a work of fiction
- Queen Machina, one of the main villains from Power Rangers Zeo
- Machina, Nigeria, a Local Government Area in Yoba State
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