Surname
- Annamma Mathew (1922–2003), chief editor of largest selling women's magazine in India, wife of K.M. Mathew
- Arnold Mathew (1852–1919), first Old Catholic bishop in the United Kingdom
- Biju Mathew, Indian-American activist
- Brian Mathew (born 1936), British botanist
- C. V. Mathew, Indian bishop
- Charles James Mathew (1872–1923), British lawyer and politician
- Cyril Mathew (c.1912–1989), Sri Lankan politician and writer
- David Mathew (disambiguation)
- Eduardo Mathew (born 1973)
- Edward Mathew (British general) (1729–1805), fought in the American Revolutionary War
- Francis James Mathew, 2nd Earl Landaff (1768–1833), Irish politician
- Gervase Frederick Mathew (1842–1928), English naval officer and entomologist
- Harriet Mathew, 18th century London socialite and patron of the arts
- Hywel ap Syr Mathew (died 1581), Welsh poet, genealogist and soldier
- John Mathew (1849–1929), Australian Presbyterian minister and anthropologist
- K. K. Mathew 1911–1992), Indian Supreme Court judge
- K. M. Mathew (1917–2010), chief editor of leading Malayalam newspaper in Kerala, India
- KM Mathew, pen-name Ekalavyan, (1934–2012), Indian writer
- Karthika Mathew, Indian actress
- Kuzhivelil Mathew (born 1931), Indian biblical scholar
- Lazar Mathew, Indian medical academic
- Montague James Mathew (1773–1819), Irish politician and British Army general
- Nikhil Mathew (born 1984), singer from Kerala, India
- Oommen Mathew (born 1939), Indian politician
- Ray Mathew (1929–2002), Australian author
- Rebekka Mathew (born 1986), Danish pop singer
- Robert Mathew (1911–1966), British Barrister and politician
- Sarah Louise Mathew (c.1805–1890), New Zealand diarist
- Simon Mathew (born 1984), Danish pop singer
- Suleka Mathew, Canadian actress
- Sushanth Mathew (born 1981), Indian football player
- Theobald Mathew (disambiguation)
- M. Thomas Mathew (born 1940), Indian literary critic
- Trevin Mathew (born 1978), Sri Lankan cricketer
- Vineeth Revi Mathew (born 1984), Indian professional basketball player
- Mathew (horse), Winner of the 1847 Grand National
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