McCune stands for:
- People
- Adam McCune (novelist) (born 1985), American novelist
- Adam McCune (columnist), American columnist and freelance writer
- Alfred W. McCune (b. 1849), British-American railroad builder, mine owner, and Mormon
- Barron Patterson McCune (1915–2008), United States federal judge
- Debbie McCune Davis (b. 1951), American politician
- Emma McCune (1964-1993), British foreign aid worker
- George M. McCune (1908-1948), co-developer of the McCune-Reischauer Romanization system of the Korean language
- Grant McCune (1943–2010), American special effects designer
- Isaac McCune (1884–unknown), Canadian politician
- Keith McCune (b. 1955), American author
- Lisa McCune (b. 1971), Australian actress
- Robert McCune (b. 1979), American football player
- Rolland D. McCune (b. 1934), American theologian
- Sara Miller McCune (b. 1941) is the co-founder and Chair of SAGE Publications
- Shannon Boyd-Bailey McCune (1913-1993), geographer and brother of George M. McCune
- William McCune (1953–2011), American computer scientist
- Places
- McCune, Kansas, a small town in the United States
- Business
- McCune Audio/Video/Lighting, a professional event production company in the San Francisco Bay Area
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