MDI may refer to:
In computer science:
- Media Delivery Index, a metric used in IPTV networks
- Medium Dependent Interface, a type of Ethernet port connection
- Microsoft Document Imaging Format, a proprietary file format
- Mission Data Interface, an interface developed by NUWC Keyport
- Multiple document interface, a type of software application interface
In health:
- Mini dental implant
- Major Depression Inventory, a self-report mood inventory developed by the World Health Organization
- Metered-dose inhaler, a device that helps deliver a specific amount of medication to the lungs
- Multiple Drug Intake, an unnatural cause of death
- Multiple Daily Injections, a technique of intensive insulinotherapy
In organizations:
- Management Development Institute, a business school in Gurgaon, India
- Men's Divisions International, a non-profit men's organization in North America
- Merchants Distributors, Inc., a wholesale grocery store distributor based in Hickory, North Carolina
- Movement for Democracy and Independence, a former political party in the Central African Republic
- Motor Development International, a compressed air car maker
In other uses:
- Mount Desert Island, an island off the coast of the U.S. state of Maine
- Methylene diphenyl diisocyanate, a chemical
- Michelson Doppler Imager, an instrument on board the SOHO spacecraft
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