Medrano may refer to:
- People
- Carlos Monge Medrano, (1884-1970), Peruvian physician
- Diego Medrano, (born 1978), Spanish poet, narrator and columnist
- Enric Casadevall Medrano, Andorran politician
- Francisco Medrano (footballer), (born 1983), Salvadoran football player
- Francisco Medrano (poet), 16th–17th century Spanish poet
- Giovanni Antonio Medrano, (1703-1760), Italian architect
- Héctor Medrano, (born 1967), Mexican football manager
- Ingrid Medrano, (born 1979), Savadoran wrestler
- José Alberto Medrano, former Salvadoran general
- Jose Domingo Medrano, (born 1921), Salvadoran doctor
- Juan de Espinosa Medrano, (ca. 1629-1688), Peruvian author
- Orlando Montenegro Medrano, (died 1988), former President of Nicaragua
- Pedro Medrano, (1769-1840), Argentine statesman and lawyer
- Rosa Medrano, (born 1985), Dominican professional volleyball player
- Medrano Tamen, (born 1986), Cameroonian footballer
- Places
- Medrano, Spain, a municipality in La Rioja, Spain
- Juan Espinoza Medrano District, a district in Peru
- Medrano (Buenos Aires Metro), a metro station in Buenos Aires, Argentina
- Entertainment and media
- Cirque Medrano, a French circus
- General Medrano, an enemy of James Bond in the film Quantum of Solace
- Lily Medrano, a character from Gaano Kadalas ang Minsan