MNS may refer to:
- Maharashtra Navnirman Sena, a Maharashtrian nationalist party in Maharashtra.
- The Malaysian Nature Society
- Maki-Nakagawa-Sakata matrix
- Ministry of National Security
- Minneapolis, Northfield and Southern Railway
- Minnesota North Stars, ice hockey team in the National Hockey League
- Mission Need Statement
- M. Night Shyamalan, a film director
- MNS antigen system, a variant blood group
- Monday Night Soccer, an Irish soccer programme dedicated to the League of Ireland, broadcast by RTÉ.
- Wall Street: Money Never Sleeps, a 2010 movie.
- Motor neurone disease
- Movement for a New Society
- National Syndicalists (Portugal), Movimento Nacional-Sindicalista
- Movimiento Nacional Socialista de Chile
- Manganese(II) sulfide, an inorganic chemical compound of manganese and sulfur.
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