MRF is an acronym which may refer to:
- Biology
- Myelin gene Regulatory Factor a protein of critical importance in the development and maintenance of myelin
- Myogenic regulatory factor
- Organizations
- Medical Response Force
- Movement for Rights and Freedoms, a Bulgarian political party
- Mobile Riverine Force (United States Navy)
- Morgellons Research Foundation
- Military Reaction Force, a British military unit in Belfast
- Meningitis Research Foundation, a British and Irish charity
- Companies
- Madras Rubber Factory
- Møre og Romsdal Fylkesbåtar, a Norwegian transportation company
- Concepts
- Markov random field
- Multiple reference frame (video), a concept in video compression
- Medium Range Forecast model
- Media Resource Function Server (MRF) for IP Multimedia Subsystem (IMS)
- Other
- Magnetorheological Finishing
- Materials Recovery Facility
- Multi-role fighter, a military airplane capable of undertaking different missions
- airport code for Marfa Airport in Marfa, Texas
- National Rail station code for Moorfields railway station, Liverpool, England
- Myspace Rated Freak
- Mentally Retarded Female (Arrested Development)
- Mississippi River Festival
- Modification Request Form
- Material Request Form