Musser is a surname. It can refer:
- A. Milton Musser (1830–1909), Mormon pioneer
- Alec Musser (b. 1973), American fitness model and actor
- Charles Musser (b. 1951), American film scholar
- Clair Omar Musser (1901-1998), American marimba virtuoso, designer, and composer
- Danny Musser (1905–2000), American professional baseball player
- David Musser (contemporary), American computer scientist
- George Musser (b. 1965), American science writer
- Guy Musser (b. 1936), American zoologist
- Joseph White Musser (1872–1954), Mormon fundamentalist leader
- Kenneth Musser (contemporary), American politician from Illinois
- Neal Musser (b. 1980), American professional baseball player
- Paul Musser (1889–1973), American professional baseball player
- Pete Musser (b. 1928), American businessman
- Tharon Musser (b. 1925), American Broadway lighting designer
- Willard Isaac Musser (1913–2003), American trumpeter, composer, music teacher and director
- Luke Musser(2003-)boss professional football player#22
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