Mylene or Mylène is a given name, a contraction of Marie-Helène, which may refer to:
- Mylène Farmer, a French singer-songwriter
- Mylène Jampanoï, a French actress, born in 1980
- Mylène Demongeot, a French actress, born in 1936
- Mylène Dressler, an American author
- Mylène Lamoureux, a Canadian ice-dancer
- Mylene Flare Jenius, a fictional character in the Macross universe
- Mylène Paquette, a Canadian ocean rower
Also:
- Myleene Klass, British entertainment personality