The acronym NASC can refer to:
- National Access and Scaffolding Confederation, a national trade body for access and scaffolding in the UK
- National Association of State Comptrollers
- National Association of Student Councils, a U.S. student organization
- National Aeronautics and Space Council
- Naval Air Systems Command (NAVAIR), the command of the United States Navy which provides material support for naval aircraft and airborne weapons systems
- Necessary and sufficient condition, in logic and mathematics
- New Age Standard Comic, the subtitle of Monthly Dragon Age.
- North American Solar Challenge, a solar car race in the United States and Canada
- North American Spondylitis Consortium, a genetic project funded through the University of Texas Health Science Centre, Houston
- North Augusta, South Carolina
- Nottingham Arabidopsis Stock Centre, the European collection and distribution centre for the model plant Arabidopsis
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