Needham is a surname, and may refer to:
- Ben Needham, British infant missing since 1991
- Col Needham, co-founder of the Internet Movie Database
- David Needham, English football player
- Ernest Needham (1873–1936), English football player
- Francis Needham, 3rd Earl of Kilmorey (1842–1915), 3rd Earl of Kilmorey
- Hal Needham, American stuntman
- Jack Needham, English football player
- James George Needham (1868–1957), American entomologist
- John Needham (1713–1781), British biologist and Roman Catholic priest who believed in the theory of spontaneous generation
- Joseph Needham, British biochemist and pre-eminent authority on the history of Chinese science
- Marchamont Needham, English political pamphleteer
- Richard Needham, 6th Earl of Kilmorey (1942– ), British politician
- Richard J. Needham (1912–1996), Canadian newspaper columnist and humorist
- Rodney Needham (1923–2006), British social anthropologist
- Roger Needham, British computer scientist
- Samuel Needham VC, British soldier
- Tracey Needham, American actress
- Tristan Needham, British mathematician
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