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- Eeke van Nes (born 1969), Dutch rower
- Hadriaan van Nes (born 1942), Dutch rower
- Nes (fish), a genus of gobies in subfamily Gobiinae
- Nintendo Entertainment System, video gaming system
- NISC Export Services, IT services company
- Netscape Enterprise Server (predecessor of Sun Java System Web Server)
- Nuclear export signal, an amino acid sequence causing a protein to be exported from the nucleus to the cytoplasm
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