NGC is an acronym that may refer to:
- New General Catalogue of Nebulae and Clusters of Stars, a catalogue of deep sky objects in astronomy
- NGC Corporation, which became Dynegy Inc
- NGC Magazine, an unofficial Nintendo magazine in the United Kingdom
- National Gallery of Canada, a Canadian art museum
- National Gas Company of Trinidad and Tobago, a state-owned natural gas company
- National Grid plc, a former name of National Grid Electricity Transmission plc, the operator of the British electricity transmission system
- National Geographic Channel, an international documentary television channel
- Nevada Gaming Commission, regulator of gaming in the State of Nevada, USA
- New Graduate College, at Princeton University
- Nintendo GameCube, a video game console
- Northrop Grumman Corporation, an aerospace and defense conglomerate
- Numismatic Guaranty Corporation, a coin grading service
- North German Confederation, the successor to the German Confederation
- Pearland NGC
- Carmiooro NGC, a professional cycling team, whose license is held in Great Britain, founded in 2008 by Lorenzo Di Silvestro who is Team Manager and Natale Bellotti, the team's President
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