Nike may refer to:
- Nike (mythology), Greek goddess who personifies victory
- The Nike of Samothrace, an ancient statue of the goddess Nike
- Nike, Inc., major U.S. manufacturer of athletic shoes, apparel, and sports equipment
- Project Nike, US Army missile project
- MIM-14 Nike-Hercules, solid fuel propelled surface-to-air missile
- Various U.S. sounding rockets named after the upper stage used, including:
- Nike Apache
- Nike-Cajun
- Nike Hawk
- Nike Iroquois
- Nike Nike
- 307 Nike, sizeable asteroid in the main belt
- Nike Award, Polish language literature prize
- Nike (name), surname and feminine given name
- Nike, a fictional character in The Underland Chronicles children's books by Suzanne Collins
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