OAS or Oas may refer to:
- Organization of American States, an international organization of the Americas
- Ohio Auction School, an auction school in Ohio, USA
- Old Age Security, a social security payment available to most Canadians aged 65 or older
- Oracle Application Server, an integrated, standards-based software platform
- Oral allergy syndrome, an allergic reaction to certain fruits, nuts, and vegetables that develops in hay fever sufferers
- Organisation de l'armée secrète, a short-lived, French far-right paramilitary organization during the Algerian War
- OAS1, OAS2, OAS3, human genes on chromosome 12 encoding the anti-viral enzymes oligoadenylate synthetase
- Option-adjusted spread, the flat spread over the treasury yield curve required to discount a security payments to match its market price
- Open-Architecture-System, the main user interface of the Wersi keyboard line
- The Odd Angry Shot, an Australian film
- Oas, Albay, a municipality in the Philippines
- O-Acetylserine, an amino-acid involved in cysteine synthesis
- Ontario Archaeological Society, an organization promoting archaeology within the Province of Ontario, Canada
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