Computing
- Orion (system-on-a-chip)
- ORION (Research and Education network)
- Ferranti Orion, a mid-range mainframe computer introduced in 1959
- HLH Orion, a series of minicomputers produced in the 1980s
- Orion Application Server
- Orion (music software), a music production software program
- Orion quantum computing system
- Orion, a characters in Maxis' role playing game Darkspore
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