ORL can refer to several things:
- Omar Rodríguez-López, leader of The Mars Volta
- IATA airport code for Orlando Executive Airport
- Olivetti Research Laboratory
- Orlando, Florida
- Orlando Magic
- Oil Refineries Ltd
- Otolaryngology is sometimes referred to as ORL
- Optical return loss in fiber optics and telecommunications
- "Opioid Receptor-Like receptor" in neurobiology, now known as the Nociceptin receptor