Structure
The PheOH monomer (51.9 kDa) consists of three distinct domains: a regulatory N-terminal domain (residues 1-117), the catalytic domain (residues 118-427), and a C-terminal domain (residues 428-453) responsible for oligomerization of identical monomers. Extensive crystallographic analysis has been performed, especially on the pterin- and iron-coordinated catalytic domain to examine the active site. The structure of the N-terminal regulatory domain has also been determined, and together with the solved structure of the homologous tyrosine hydroxylase C-terminal tetramerization domain, a structural model of tetrameric PheOH has been proposed.
Read more about this topic: Phenylalanine Hydroxylase
Famous quotes containing the word structure:
“Vashtar: So its finished. A structure to house one man and the greatest treasure of all time.
Senta: And a structure that will last for all time.
Vashtar: Only history will tell that.
Senta: Sire, will he not be remembered?
Vashtar: Yes, hell be remembered. The pyramidll keep his memory alive. In that he built better than he knew.”
—William Faulkner (18971962)
“... the structure of our public morality crashed to earth. Above its grave a tombstone read, Be toleranteven of evil. Logically the next step would be to say to our commonwealths criminals, I disagree that its all right to rob and murder, but naturally I respect your opinion. Tolerance is only complacence when it makes no distinction between right and wrong.”
—Sarah Patton Boyle, U.S. civil rights activist and author. The Desegregated Heart, part 2, ch. 2 (1962)
“Science is intimately integrated with the whole social structure and cultural tradition. They mutually support one otheronly in certain types of society can science flourish, and conversely without a continuous and healthy development and application of science such a society cannot function properly.”
—Talcott Parsons (19021979)