Piero may refer to:
- Piero della Francesca (c1415-1492), an Italian artist of the Early Renaissance
- Piero De Benedictis (b1945), an Italian-born Argentine and Colombian folk singer
- Piero the Unfortunate (1472–1503), Gran maestro of Florence
- Alessandro Del Piero (born 1974), Italian footballer
- Gloria De Piero (born 1972), British politician
- Gregory Del Piero (born 1972), French music producer
- Maestro Piero (c1300-c1350), Italian medieval composer
- Tommaso di Piero (1464–1529), Italian painter
- W. S. Di Piero (born 1945), American poet, translator, essayist, and educator
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