PPO is a three letter acronym for:
- 2,5-Diphenyloxazole, an organic scintillator
- Personal Protection Officer
- Pfadfinder und Pfadfinderinnen Österreichs
- Planned purchase order, a suggestion by a MRP system that can become a purchase order
- Polish Patent Office
- Polyphenol oxidases, a family of enzymes
- Poly(p-phenylene oxide)
- Preferred Provider Organization or "Participating Provider Option", a type of health insurance plan
- Propylene oxide, an industrial chemical
- Prisons and Probation Ombudsman
- Pure plant oil
- Toray Pan Pacific Open, a Women's Tennis Association tournament
- The Plumber's Philharmonic Orchestra, an orchestra based at McGill University in Montreal Quebec
- Professional Photographers of Ontario
- Platelet Peroxidase, enzyme(s) in platelets with peroxidase activity
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