Fictional Characters
- Becky Preston, from the Shiloh movies
- Bill S. Preston Esq., one half of Bill and Ted, played by Alex Winter
- Dara Lynn Preston, from the Shiloh movies
- Marty Preston, from the Shiloh movies
- Sergeant Preston of the Yukon
- Dr. Preston Burke, Grey's Anatomy
- Preston the robot dog in the Wallace and Gromit film A Close Shave
- Preston of the Spaceways, a fictional character from the Honorverse
- Preston (played by Colin Hanks), Carl Denham's assistant in King Kong (2005 film)
- Cleric John Preston (played by Christian Bale), Equilibrium (film)
- Preston Winthrop from MySims Agents
- John James Preston, the full name of Mr. Big (Sex and the City), Carrie Bradshaw's love interest in the Sex and the City television series and ensuing films.
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