Prostaglandin - Types

Types

The following is a comparison of different types of prostaglandin, prostacyclin I2 (PGI2), prostaglandin E2 (PGE2), and prostaglandin F2α (PGF2α).

Type Receptor Function
PGI2 IP
  • vasodilation
  • inhibit platelet aggregation
  • bronchodilation
PGE2 EP1
  • bronchoconstriction
  • GI tract smooth muscle contraction
EP2
  • bronchodilation
  • GI tract smooth muscle relaxation
  • vasodilation
EP3
  • ↓ gastric acid secretion
  • ↑ gastric mucus secretion
  • uterus contraction (when pregnant)
  • GI tract smooth muscle contraction
  • lipolysis inhibition
  • ↑ autonomic neurotransmitters
  • ↑ platelet response to their agonists and ↑ atherothrombosis in vivo
Unspecified
  • hyperalgesia
  • pyrogenic
PGF2α FP
  • uterus contraction
  • bronchoconstriction

Read more about this topic:  Prostaglandin

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