Publication Bias - Remedies

Remedies

Ioannidis' remedies include:

1. Better powered studies
   • Low-bias meta-analysis
   • Large studies where they can be expected to give very definitive results or test major, general concepts
2. Enhanced research standards including
   • Pre-registration of protocols (as for randomized trials)
   • Registration or networking of data collections within fields (as in fields where researchers are expected to generate hypotheses after collecting data)
   • Adopting from randomized controlled trials the principles of developing and adhering to a protocol.
3. Considering, before running an experiment, what they believe the chances are that they are testing a true or non-true relationship.
   • Properly assessing the false positive report probability based on the statistical power of the test
   • Reconfirming (whenever ethically acceptable) established findings of "classic" studies, using large studies designed with minimal bias