Quetiapine - Synthesis

Synthesis

At first the lactam was treated with phosphoryl chloride and the 11-chlorodibenzothiazepine was synthesised. During a nucleophilic substitution the sidechain is built.

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    It is in this impossibility of attaining to a synthesis of the inner life and the outward that the inferiority of the biographer to the novelist lies. The biographer quite clearly sees Peel, say, seated on his bench while his opponents overwhelm him with perhaps undeserved censure. He sees him motionless, miserable, his head bent on his breast. He asks himself: “What is he thinking?” and he knows nothing.
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