RANKL
Gene Ontology | |
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Molecular function | • cytokine activity • tumor necrosis factor receptor binding • tumor necrosis factor receptor superfamily binding |
Cellular component | • extracellular region • extracellular space • cytoplasm • integral to plasma membrane |
Biological process | • ossification • monocyte chemotaxis • immune response • activation of JUN kinase activity • organ morphogenesis • positive regulation of intracellular protein kinase cascade • cytokine-mediated signaling pathway • osteoclast differentiation • tumor necrosis factor-mediated signaling pathway • mammary gland epithelial cell proliferation • positive regulation of homotypic cell-cell adhesion • positive regulation of I-kappaB kinase/NF-kappaB cascade • positive regulation of MAP kinase activity • bone resorption • positive regulation of osteoclast differentiation • positive regulation of bone resorption • positive regulation of transcription from RNA polymerase II promoter • positive regulation of JNK cascade • positive regulation of T cell activation • positive regulation of sequence-specific DNA binding transcription factor activity • positive regulation of NF-kappaB transcription factor activity • protein homooligomerization • positive regulation of corticotropin-releasing hormone secretion • positive regulation of protein kinase B signaling cascade • mammary gland alveolus development • ERK1 and ERK2 cascade • positive regulation of fever generation by positive regulation of prostaglandin secretion • TNFSF11-mediated signaling pathway • positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling |
Sources: Amigo / QuickGO |
43.14 – 43.18 Mb
78.28 – 78.31 Mb
- Not to be confused with RANK, the osteoclast cell-surface receptor that binds to RANKL.
Receptor activator of nuclear factor kappa-B ligand (RANKL), also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11), TNF-related activation-induced cytokine (TRANCE), osteoprotegerin ligand (OPGL), and osteoclast differentiation factor (ODF), is a protein that in humans is encoded by the TNFSF11 gene.
Critical for adequate bone metabolism, this surface-bound molecule (also known as CD254) found on osteoblasts serves to activate osteoclasts, which are the cells involved in bone resorption. Osteoclastic activity is triggered via the osteoblasts' surface-bound RANKL activating the osteoclasts' surface-bound receptor activator of nuclear factor kappa-B (RANK).
Read more about RANKL: Function, Animal Models, See Also
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