RANKL

RANKL

Identifiers Symbols TNFSF11; CD254; ODF; OPGL; OPTB2; RANKL; TRANCE; hRANKL2; sOdf External IDs OMIM: 602642 MGI: 1100089 HomoloGene: 2744 GeneCards: TNFSF11 Gene

Gene Ontology
Molecular function cytokine activity
tumor necrosis factor receptor binding
tumor necrosis factor receptor superfamily binding
Cellular component extracellular region
extracellular space
cytoplasm
integral to plasma membrane
Biological process ossification
monocyte chemotaxis
immune response
activation of JUN kinase activity
organ morphogenesis
positive regulation of intracellular protein kinase cascade
cytokine-mediated signaling pathway
osteoclast differentiation
tumor necrosis factor-mediated signaling pathway
mammary gland epithelial cell proliferation
positive regulation of homotypic cell-cell adhesion
positive regulation of I-kappaB kinase/NF-kappaB cascade
positive regulation of MAP kinase activity
bone resorption
positive regulation of osteoclast differentiation
positive regulation of bone resorption
positive regulation of transcription from RNA polymerase II promoter
positive regulation of JNK cascade
positive regulation of T cell activation
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of NF-kappaB transcription factor activity
protein homooligomerization
positive regulation of corticotropin-releasing hormone secretion
positive regulation of protein kinase B signaling cascade
mammary gland alveolus development
ERK1 and ERK2 cascade
positive regulation of fever generation by positive regulation of prostaglandin secretion
TNFSF11-mediated signaling pathway
positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 8600 21943 Ensembl ENSG00000120659 ENSMUSG00000022015 UniProt O14788 O35235 RefSeq (mRNA) NM_003701 NM_011613 RefSeq (protein) NP_003692 NP_035743 Location (UCSC) Chr 13:
43.14 – 43.18 Mb Chr 14:
78.28 – 78.31 Mb PubMed search
Not to be confused with RANK, the osteoclast cell-surface receptor that binds to RANKL.
"TRANCE" redirects here. For other uses, see Trance (disambiguation).

Receptor activator of nuclear factor kappa-B ligand (RANKL), also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11), TNF-related activation-induced cytokine (TRANCE), osteoprotegerin ligand (OPGL), and osteoclast differentiation factor (ODF), is a protein that in humans is encoded by the TNFSF11 gene.

Critical for adequate bone metabolism, this surface-bound molecule (also known as CD254) found on osteoblasts serves to activate osteoclasts, which are the cells involved in bone resorption. Osteoclastic activity is triggered via the osteoblasts' surface-bound RANKL activating the osteoclasts' surface-bound receptor activator of nuclear factor kappa-B (RANK).

Read more about RANKL:  Function, Animal Models, See Also