Rhein may refer to
- the German word for the Rhine, a major river in Europe
- Rhein (molecule), a substance in the anthraquinone group found in rhubarb
- Rhein, Saskatchewan, a community in Canada
- Eduard Rhein (1900–1993), a German inventor, publisher and author
- Ralph Rhein (born 1965), a Swiss slalom canoer
- SMS Rhein, a 1871 steam-powered ironclad monitor of the German Imperial Navy
- SS Rhein (1899), an ocean liner for North German Lloyd
- Rhein, a German blockade runner scuttled in the Florida Strait during the Second World War
and also:
- Rhein in Ostpreußen, a town in Germany, now Ryn in Poland
- Rhein Fire, a defunct professional American football team in NFL Europe
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