Rickettsiaceae - Genomics

Genomics

Comparative genomic analysis has identified 3 proteins, RP030, RP187 and RP192, which are uniquely found in members of the family Rickettsiaceae and serve as molecular markers for this family. In addition, conserved signature indels in a number of proteins including a 4 amino acid insert in transcription repair coupling factor Mfd, a 10 amino acid insert in ribosomal protein L19, 1 amino acid inserts each in the FtsZ protein and the major sigma factor 70, and a 1 amino acid deletion in exonuclease VII protein that are specific for the Rickettsiaceae species have been identified.