Rothman is a surname. Notable people with the surname include:
- Barbara Katz Rothman (born 1948), sociologist
- Benny Rothman (1911–2002), political activist
- David Rothman (statistician) (1935–2004), statistician
- David Rothman, professor of medicine
- Einar Rothman (1888–1952), track and field athlete
- Elise Rothman, fictional character from the television series Charmed
- Gertjan Rothman (born 1983), footballer
- Göran Rothman (1739–1778), naturalist and physician
- James Rothman, American cell biologist
- John Rothman (born 1949), actor
- Judy Rothman is an American screenwriter and lyricist
- Katherine Rothman
- Ken Rothman (born 1935), American politician; Lieutenant Governor of Missouri
- Lorraine Rothman (1932–2007), activist
- Louis Rothman (1869–1926), founder of Rothmans International
- Makua Rothman (born 1984), surfer
- Mark Rothman, writer
- Milton A. Rothman (1919–2001), nuclear physicist
- Norman Rothman (1914–1985), gangster
- Richard B. Rothman, pharmacologist
- Rodney Rothman, screenwriter
- Sandy Rothman, bluegrass musician and producer
- Stephanie Rothman (born 1936), film director
- Steve Rothman (born 1952), politician
- Thomas Rothman (born 1954), CEO of FOX Filmed Entertainment
- Tony Rothman (born 1953), physicist
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