Roxanne may refer to:
- Hurricane Roxanne, a major hurricane in October 1995
- "Roxanne" (song), a 1978 song by The Police
- A main character and love interest in Edmond Rostand's play Cyrano de Bergerac
- Roxanne (film), a 1987 movie adaptation of this play with Steve Martin and Daryl Hannah
- Roxanne (Pokémon), a character in the Pokémon universe
- Roxanne (model), the assistant on the 1950-1961 game show Beat the Clock
- Roxanne Emery, the English singer
- Roxanne (band), a band active in the late 1980s