RUC may refer to:
- RĂ¡dio Universidade de Coimbra or Coimbra University Radio, a Portuguese university station
- Rapid Update Cycle, an atmospheric prediction system
- Renmin University of China
- Roskilde University or Roskilde Universitetscenter
- Royal Ulster Constabulary, the police force in Northern Ireland from 1922 to 2001
- Specialty Society Relative Value Scale Update Committee or Relative Value Update Committee, an American Medical Association group involved in health care pricing
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