Sakamoto (kanji: 坂本) is the name of two villages in Japan:
- Sakamoto, Kumamoto, a small village in Kumamoto Prefecture
- Sakamoto, Shiga, a place in Shiga Prefecture, part of the city of Otsu, Shiga
Sakamoto is also a Japanese surname for several people (sorted alphabetically by given name):
- The Sakamoto family members, victims of the Sakamoto family murder perpetrated by members of the cult organization Aum Shinrikyo
- Chika Sakamoto, voice actor and singer
- Fuyumi Sakamoto, enka singer
- Hideki Sakamoto, video game composer
- John Sakamoto, Canadian journalist
- Kerri Sakamoto, Canadian novelist
- Koki Sakamoto, gymnast
- Kyu Sakamoto, pop singer well known for his song Sukiyaki in the 1960s
- Maaya Sakamoto, voice actor and singer
- Miu Sakamoto, pop singer, daughter of Ryuichi Sakamoto
- Ryuichi Sakamoto, musician and composer, as well as an actor
- KAZMA, Japanese pro-wrestler who performs in Florida Championship Wrestling under ring name Sakamoto
- Sakamoto Ryoma, military leader prior to the Meiji Restoration
- Shōgo Sakamoto, young actor and singer
- Yoshio Sakamoto, game designer for Nintendo
Fictional characters:
- Sakamoto from Maison Ikkoku (here)
- Akira Sakamoto and Harumi Sakamoto from Princess Princess (here)
- Chiyo Sakamoto from Memoirs of a Geisha
- Julietta Sakamoto from Air Master
- Sue, her brother Kazuma, and their mother Momorin Sakamoto from Cave Story
- Mio Sakamoto from Strike Witches
- Sakamoto, A kei car racer from Initial D series
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