People of the surname Saussure or de Saussure include
- Horace-Bénédict de Saussure (1740–1799), Swiss physicist and Alpine traveller
- Nicolas-Théodore de Saussure (1767–1845), chemist, son of Horace-Bénédict, and brother of Albertine
- Albertine Necker de Saussure (1766–1841), Swiss writer, educationalist, and advocate of education for women, daughter of Horace-Bénédict, and sister of Nicolas-Théodore
- Henri Louis Frédéric de Saussure (1829–1905), Swiss mineralogist and entomologist (taxonomist), and father of Ferdinand, Léopold and René.
- Ferdinand de Saussure (1857–1913), Swiss linguist, brother of Léopold and René
- Léopold de Saussure (1866–1925), sinologist, astronomer, French Naval Officer, brother of Ferdinand and René
- René de Saussure (1868–1943), Swiss Esperantist and scientist, brother of Ferdinand and Léopold
- Hermine de Saussure (1901–1984), female sailing pioneer and scholar, specialist of Jean-Jacques Rousseau daughter of Léopold and mother of Delphine Seyrig
- Éric de Saussure (1925–2007), Swiss artist and member of the Taizé Community
- Henry William de Saussure (1763–1839) American lawyer, State legislator from South Carolina, President of the U.S. Mint
- William F. De Saussure (1792–1870), U.S. Senator from South Carolina
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