SB or Sb may refer to:
- Spina bifida
- S.B., ScientiƦ Baccalaureus or Bachelor of Science, an academic degree
- Senate Bill, especially when quoting a bill's code (e.g. "SB 1234")
- Sonderbehandlung, a German euphemism used during the Nazi era denoting murder
- Substantive, a term for noun
- Intel Sandy Bridge, an Intel processors codename
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