SD may refer to:
- Salvia divinorum, a psychoactive plant
- Sekolah Dasar, an Indonesian junior school
- Sindhi language's ISO 639-1 code
- Sisters of the Destitute, a Syro-Malabar Catholic women's order
- Sleeping Dogs, a 2012 video game
- Slobodna Dalmacija, a newspaper
- Southern Cross Decoration (SD), a South African military award
- Spasmodic dysphonia
- Sudan Airways' IATA airline designator
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