Sep or SEP may refer to:
- September, a month
- SEP (Vehicle)
- SEP IRA, a type of retirement account
- Sęp, Świętokrzyskie Voivodeship, a village in Poland
- Septentrional or Sep., the North direction or zone
- Sepultura, heavy metal band
- Scottish Equity Partners
- Secretaría de Educación Pública, a Mexican government department
- Specialna Enota Policije, a police unit in Slovenia
- Signaling End Point
- Slug (rapper) (born 1972), also known as Sep Seven
- Socialist Equality Party (disambiguation), several political parties
- Sociedade Esportiva Palmeiras, a Brazilian football team
- Society for Exact Philosophy
- Solar Electric Propulsion
- Somebody Else's Problem
- Standards-essential patent
- Stanford Encyclopedia of Philosophy
- Stanford Exploration Program
- Summer Enrichment Program, any of various similarly named programs, including
- Summer Enrichment Program (University of Colorado)
- Summer Enrichment Program (University of Virginia)
- Symantec Endpoint Protection, computer security software
- South ecliptic pole
- System Enhancement Package, an upgrade to the M1A2 Abrams main battle tank
- Somatosensory Evoked Potential
- Single Engine Piston, a pilot's rating class
- Solar Energetic Particle
- Dutch dialect for liquorice (drop)
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