Shackleton may refer to:
- Avro Shackleton, a maritime patrol aircraft
- Ernest Shackleton, explorer best known as the leader of the Imperial Trans-Antarctic Expedition, 1914–17
- Shackleton (musician), dubstep producer
- Shackleton (surname), people with the surname Shackleton
- Shackleton (crater), a crater at the south pole of the Moon
- Shackleton (miniseries), a UK television miniseries on Ernest Shackleton, starring Kenneth Branagh
- RRS Ernest Shackleton, a ship used by the British Antarctic Survey
- RRS Shackleton, a similarly named ship of the British Antarctic Survey that served in the 1950s and 1960s
- The Shackeltons, a Pennsylvania based rock group
- Shackleton, Western Australia
- Shackleton Hall, a hall of residence at the University of Birmingham
- Shackleton's Antarctic Adventure, an IMAX film narrated by Kevin Spacey