Shu may refer to:
- Shu (Egyptian deity)
- 蜀 (Shǔ), an abbreviation of Sichuan province of the People's Republic of China, as well as the following historical regimes that have existed in this region:
- Shu (state) (蜀国/蜀國 or 古蜀), a state during the Zhou Dynasty era (c. 1046 BCE – c. 316)
- Shu Han (蜀汉/蜀漢), a state that existed during the Three Kingdoms Period (221–263)
- Cheng Han (成汉/成漢), also named Later Shu (后蜀/後蜀), one of the Sixteen Kingdoms (304–347)
- Western Shu (西蜀), also named Qiao Shu (谯蜀/譙蜀), one of the units of the Eastern Jin period (405–413)
- Former Shu (前蜀), one of the divisions of the Five Dynasties and Ten Kingdoms period (907–925)
- Later Shu (后蜀/後蜀), one of the divisions of the Five Dynasties and Ten Kingdoms period (934–965)
- the Kazakh name for the Chui River
- Shu, Kazakhstan
- The ancient Chinese Classic of History (Shū 書)
- People
- Shu, the guitarist in the Japanese rock band, BACK-ON
- Frank Shu (born 1943), Chinese-American professor of astronomy
- Dong Zhongshu, Han Dynasty Chinese scholar
- Fictional characters
- Shu, the main character in the Xbox 360 game Blue Dragon
- Shu, a character in the Dragon Ball franchise
- Shu (Suikoden), a character in the video game Suikoden II
- Shu Shirakawa, a recurring character in the Super Robot Wars video game series
- Shū, a fictional character in the Fist of the North Star manga and anime franchise
- Shu, a fictional character in the manga series Hikaru no Go
- Shuzo "Shu" Matsutani, a character in the anime series Now and Then, Here and There and Legendz
SHU may be an acronym for:
- Sacred Heart University, in Fairfield, Connecticut
- Scoville Heat Unit, a measurement of hotness or spiciness in food
- Security Housing Unit, a solitary confinement space in a maximum security prison
- Seton Hall University, in South Orange, New Jersey
- Seton Hill University, in Greensburg, Pennsylvania
- Shanghai University (上海大学), in Shanghai, China
- Sheffield Hallam University, a modern university in Northern England
- Shih Hsin University (世新大學), in Taipei, Taiwan
- Special Handling Unit, a super maximum security prison located in Sainte-Anne-des-Plaines, Quebec
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