S&M may refer to:
- Sadomasochism, a form of physical role-playing
- S&M (album), a 1999 live music album by Metallica and the San Francisco Symphony Orchestra
- S&M (Le Shok album), 2001
- "S&M" (song), by Rihanna from Loud
- The Sodor & Mainland Railway, a fictional railway in The Railway Series media
- S&M Airlines, a 1989 punk album by NOFX
- "S&M", a song by Thin Lizzy from Black Rose: A Rock Legend
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