Sosa may refer to:
- a Spanish surname. Famous Sosas include:
- Alex Sosa, a fictional drug lord from the 1983 film Scarface
- Arlenis Sosa, Dominican Model
- David Sosa, American philosopher, son of Ernest Sosa
- Elías Sosa (born 1950), Dominican Republic baseball player
- Edgar Sosa (born 1979), Mexican boxer
- Edgar Sosa (born 1988), American–Dominican basketball player
- Ernest Sosa, American philosopher, father of David Sosa
- Francisco Sosa, Paraguayan football forward
- Gilberto Sosa, Mexican boxer
- Jeronimo de Sosa, Spanish genealogist
- Jorge Sosa, Dominican baseball pitcher
- José Ernesto Sosa, Argentine footballer
- José José (born José Rómulo Sosa Ortiz), Mexican singer
- Julio Sosa, Uruguayan tango singer
- Mercedes Sosa, Argentine singer
- Porfirio Lobo Sosa, Honduran politician
- Roberto Sosa, Argentine footballer
- Sammy Sosa (born 1968), Dominican baseball player
- Tomás Méndez Sosa, Mexican singer and composer
- Sōsa, Chiba, Japan
- Sosa, Germany, a town in the district of Aue-Schwarzenberg in Saxony
- Sosa, India, a village in Pithoragarh district, Uttarakhand, India
- SoSA, Oklahoma City, an inner-city neighborhood in Oklahoma City
- Sosa Method or Sosa-Stradonitz Method, a genealogical numbering system commonly called Ahnentafel
- Sosa Station, a train station named after a district in Bucheon, South Korea
- Sosa v. Alvarez-Machain, United States Supreme Court case
- SOSA, a "System of Systems" Approach (Systems Engineering)
- SOSA, initialism for State Opera of South Australia
- Chief Keef
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