As An Abbreviation
- Saddle point approximation, a term used in quantum field theory
- Saudi Press Agency
- Scintillation proximity assay, an assay used for biochemical development and screening
- School of Planning and Architecture, India's premier architecture and city-planning institution, located in Delhi
- Scottish Publishers Association, a trade association
- Secure Password Authentication
- Self-Propelled Artillery
- Sense Plan Act, an artificial intelligence methodology used in robotics
- Separation Party of Alberta
- Seven Party Mujahideen Alliance, the alliance of Afghan mujahideen guerrillas against the Soviets
- Seychelles Port Authority
- Simple power analysis, a type of cryptographic attack
- Single Packet Authorization
- Single Page Application, a web application that is entirely contained on the client-side typically using a combination of HTML, JavaScript, and Cascading Style Sheets
- Special pale ale, a term used to designate a certain type of pale ale
- Socialist Party of America
- Socialist Party of Australia
- Società per Azioni, an Italian corporate form used by major public corporations quoted on the Italian stock exchange
- Società Piemontese Automobili, a Torino-based car manufacturer (1908-1926)
- Society for Popular Astronomy, Society for amateur astronomers in the UK
- Software Publishers Association, now known as the Software and Information Industry Association (SIIA)
- Sony Pictures Animation
- Sp.a, the "Socialistische Partij - Anders" (Socialist Party - Differently), the socialist party in Flanders
- Spathoglottis, an orchid genus
- Special Protection Area, a European Union nature conservation designation
- Special Protocol Assessment, a declaration from the FDA that a proposed Phase III clinical trial is acceptable for FDA approval.
- St. Paul Academy and Summit School, a private K-12 school in Saint Paul, Minnesota
- St Patrick's Athletic, a football (Soccer) club in Ireland
- Stochastic process algebra
- Student Peace Alliance, a student led peace organization in the United States of America
- subpoena
- Substance P antagonist, a term used in biochemistry
- Summer Performing Arts Company, a summer educational theatre program in Grand Forks, North Dakota, United States
- Supreme People's Assembly, the parliament of the Democratic People's Republic of Korea
- Sustainable Population Australia, an Australian environmental advocacy group
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