Spadina, a name used in Toronto may refer to:
- Spadina House, one of the largest mansions in Toronto, Canada, and today a museum
- Spadina Avenue, a major street in Toronto
- Spadina Expressway, a partially completed highway in Toronto (the part that is completed had been renamed Allen Road)
- Spadina (TTC), a subway station on the Yonge-University Spadina and Bloor-Danforth lines in Toronto
- 510 Spadina, a streetcar route in Toronto
- Spadina (electoral district) (1935–1988), a federal electoral district in Toronto
- Trinity—Spadina, a federal (since 1988) and provincial electoral district (since 1999) in Toronto