Spinelli is a surname, and may refer to:
- Altiero Spinelli (1907–1986), Italian advocate for European federalism and founding father of the European Union
- Ashley Spinelli, a character in the cartoon Recess.
- Damian Spinelli, a fictional character on the American soap opera General Hospital
- Giuseppe Spinelli (1694–1763), cardinal prefect of the Congregation for the Evangelization of Peoples
- Jerry Spinelli (born 1941), American author