Standoff or stand-off may refer to:
- a media production
- Standoff (TV series), a 2006-2007 Fox Broadcasting television series
- Standoff, a 1998 film written and directed by Andrew Chapman)
- Stand Off, a 2012 film written and directed by Terry George (known as Whole Lotta Sole in Europe)
- American Standoff, a 2002 American documentary about a strike
- Standoff missile, a type of missile or bomb released at a safe distance from the target which travels autonomously to the target
- AGM-154 Joint Standoff Weapon
- Standoff Land Attack Missile
- other
- Stand-off, a position in both forms of rugby football
- Standoff (separator), used in mechanics and electronics to separate two parts from one another
- A social confrontation or conflict, such as an impasse, stalemate, or Mexican standoff
- Standoff distance, a certain safe distance from a hazard or objective (live bomb, fire, artillery aimpoint, etc.) that is mandated by some kind of standard operating procedure