Toxicology - Dose Response Complexities

Dose Response Complexities

Most chemicals display a classic dose response curve - at a low dose (below a threshold), no effect is observed. Some show a phenomenon known as sufficient challenge - a small exposure produces animals that "grow more rapidly, have better general appearance and coat quality, have fewer tumors, and live longer than the control animals". A few chemicals have no well-defined safe level of exposure. These are treated with special care. Some chemicals are subject to bioaccumulation as they are stored in rather than being excreted from the body. These also receive special consideration.

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